By C.K. Chu
• updated assessment at the chemistry and biology of nucleosides • glossy artificial method • complete assurance of antiviral nucleosidesThis ebook summarizes the new advances in nucleosides chemistry and chemotherapy over the last 10-15 years. It covers lately stumbled on nucleoside antiviral brokers, their healing points and biochemistry, and likewise broad reports on their chiral synthesis.
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Extra info for Antiviral Nucleosides: Chiral Synthesis and Chemotherapy
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J. Med. Chem. 1991,34,23832389. ; Herdewijn, P. Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridines. J. Med. Chem. 1993, 36, 538-543. 20. ; Lee, C. -C; Chu, C. K. Structure-activity relationships of (F)-5-(2-bromovinyl)uracil nucleosides and related analogs as anti-herpesvirus agents. /. Med. Chem. 2000, 43, 2538-2546. 21. Bryant, M. ; Bridges, E. ; Faraj. ; Loi, A. ; Imbach, J. ; Schinazi, R. ; Sonmiadossi, J. -P. Antiviral L-nucleosides specific for hepatitis B virus infection. Antimicrob.
Chu, C. K. Current status of anti-HBV chemotherapy. Arch. Pharm. Res. 1998, 21, 89-105. ; Chu, C. ; Boudinot, F. D. Development and optimization of anti-HIV nucleoside analogs and prodrugs: a review of their cellular pharmacology, structure-activity relationships and pharmacokinetics. Adv. Drug Delivery Reviews 1999, J9, 117-151. (g) Zemlicka, J. Enantioselectivity of the antiviral effects of nucleoside analogs. Pharmacol. Ther. 2000, 85, 251-266. ; Song, G. ; Chu, C. K. Advances in antiviral agents for hepatitis B virus.