By Lev A. Blumenfeld, Alexander N. Tikhonov
The most aim of this publication is to explain in actual phrases the unusual positive aspects of "machines" having molecular dimensions that play the crucial position within the most crucial organic tactics, viz., power transduction and enzyme catalysis. when you consider that those molecular engines paintings with thermal, chemical, and mechanical power, the perfect framework to debate them comes from thermodynamics and chemical kinetics. The ebook therefore starts off with a overview of the thermodynamics and chemical kinetics. It then discusses the proposal of molecular machines, and particularly, the issues linked to utilizing thermodynamics to small structures corresponding to enzymes. The authors then flip to enzyme catalysis, discussing theoretical and experimental investigations of protein dynamics. The concluding bankruptcy bargains with strength transduction in organic membranes, targeting ATP synthesis.
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Additional resources for Biophysical Thermodynamics of Intracellular Processes: Molecular Machines of the Living Cell
As McClare stated , there is no immediate influence by the environment on the ability of ATPsynthase (or ATPase) to perform formation or hydrolysis of ATP. Really, under steady state conditions ATPsynthase (or ATPase) acts cyclically, whereas the chemical composition of the environment on both sides of the coupling membrane remains practically constant. Also, recurrent contraction and relaxation of myosin cross-bridges in the muscle's filaments can proceed cyclically if there is a sufficient amount of ATP and Ca 2+, but in practice these steps are not directly induced by the immediate change in the ATP and Ca2+ content in the medium.
405-426. 16. L. Onsager (1931). Phys. Rev. 38. 2265-2279. 17. I. Prigogine (1967). Introduction to Thermodynamics of Irreversible Processes. Wiley. New York. 18. R. Balescu (1975). Equilibrium and Non-equilibrium Statistical Mechanics. WileyInterscience. New York. 19. N. Shilov (1905). On the Coupled Oxidation Reactions. Moscow. 20. A. McQuarrie (1967). Appl. Probab. 1-66. 21. F. McClare (1971). J. Theor. Bioi. 1-34. 22. L. Hill (1977). Free Energy Transduction in Biology. Academic Press. New York.
62) This result is in the frame of the traditional approach of phenomenological linear thermodynamics of irreversible processes. , depends on the kinetic properties of the chemical system. This result may be of certain interest for the interpretation of experimental data concerning the energy transduction in certain biochemical processes. In this section we have considered the two simplest examples using the deterministic description of chemical reactions. This approach is adequate but only in the so-called thermodynamic limit when we can neglect the discrete nature of the processes considered, as well as the fluctuations of the reactants.