By F. Cavalli (auth.), Franco Cavalli (eds.)
Starting in 1986, the eu college of Oncology has improved its actions in postgraduate instructing, which consisted regularly of conventional disease-orientated classes, via selling new academic projects. this kind of is the cloister seminars, brief conferences meant for hugely certified oncologists and working with particular, arguable elements of scientific perform and examine. one other is the establishment of everlasting research teams, also referred to as job forces, the place a constrained variety of prime specialists are invited to fulfill annually with the purpose of defining the state-of-the-art and probably attaining a consensus on advancements and remedy in particular fields of oncology. This sequence of ESO Monographs used to be designed with the explicit function of disseminating the result of the main attention-grabbing of the seminars and research teams, and offering concise and up to date studies of the themes mentioned. It used to be made up our minds to maintain the structure extremely simple so as to maintain expenses to a minimal and make the monographs to be had within the shortest attainable time, hence overcoming a standard challenge in scientific literature: that of the fabric being superseded even prior to booklet. Umberto Veronesi Chairman, clinical Committee eu college of Oncology desk of Contents find out how to learn this Monograph F.CAvALLI ......... . 1 Experimental concepts for learning the improvement of Breast melanoma with exact connection with Steroid Hormones, progress components and Oncogenes R.J.B. KING . . . . . . . . . . . . . . . . . . . . . . . . .. . . . five . . .
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J Biol Chem 1978 (253):2223-2228 6. Horwitz KB, Koseki Y and McGuire WL: Estrogen of progesterone receptor in human breast cancer: role of estradiol and antiestrogen. Endocrinology 1978 (103):1742-1751 7. Huggins C and Young NC: Induction and extinction of mammary cancer. Science 1962 (137):257-262 8. Lyman SD and Jordan VC: possible mechanisms for the agonist actions ot tamoxifen and the antagonist actions of MER-2 (ethamoxytriphetol) in the mouse uterus. Biochem Pharm 1985 (34):2795-2806 9. Murphy LJ, Sutherland, Stead B, Myrphy LC and Lazarus L: Progestin regulations of epidermal growth factor receptor in human mammary carcinoma cells.
Mukku VR, Stancel OM: Regulation of Epidermal Growth Factor receptor by estrogen. J Biol Chem 1985 (17):9820-9824 57. Fanger BO, Viceps-Mdore D, Cidlowski JA: Regulation of high and low-affinity Epidermal Growth Factor receptors by glucocorticoids. Archives of Biochem Biophys 1984 (15) :141-149 58. Murphy LJ, Sutherland RL, Lazarus L: Regulation of gowth hormone and Epidermal Growth Factor receptor by progestins in breast cancer cells. Biochem Biophys Res Comm 1985 (131):767-773 59. Murphy LJ, Murphy LC, Stead B, Sutherland RL, Lazarus L: Modulation of lactogenic receptors by progetins in cultured human breast cancer cells.
These observations represent a link between the activity of steroid and polypeptide hormones, between steroid receptors and viral proteins, but their complete significance is not elucidated. provide further insight into the Recent investigations steroid relationship between growth factors, oncogenes and receptors. the v-erb-B gene from Avian It has been shown that Erythroblastosis virus (AEV) codes for the cytoplasmic domain of EGF-R which does not bind EGF and is responsible for the autophosphorylation of the receptor.