By H. Szajewska, R. Shamir, B. Koletzko
Reputation of evidence-based drugs is not just expanding swiftly, however it has develop into necessary to pediatric nutrients. beginning with a few methodological matters - discussing systemic experiences, meta-analyses and medical trials - this book then concisely summarizes present wisdom in addition to lack of expertise and uncertainty relating to chosen features of formative years nutrients. those features comprise practical gastrointestinal issues, concerns touching on several types of milk, complementary meals, enteral meals, celiac ailment or weight problems. Contents are according to facts and summarize present instructions; additionally, whilst there's no transparent proof, they supply a few nutrition for notion. total, this ebook has been written to allow the clinician to make expert judgements concerning pediatric nutrients.
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References 1 McCance RA: Food growth and time. Lancet 1962; 280:271–272. 2 Barker DJP: Fetal origins of coronary heart disease. BMJ 1995;311:171–174. 3 McCay CM: Is longevity compatible with optimum growth? Science 1933;77:410–411. 4 Ozanne SE, Hales CN: Catch-up growth and obesity in male mice. Nature 2004;427:411–412. 5 Barker DJP, Winter PD, Osmond C, Margetts B, Simmonds SJ: Weight in infancy and death from ischaemic heart disease. Lancet 1989;334:577–580. 6 Agostoni C, Braegger C, Decsi T, Kolacek S, Koletzko B, Michaelsen KF, Mihatsch W, Moreno LA, Puntis J, Shamir R, Szajewska H, Turck D, van Goudoever J: Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition.
Body weight, bone mineral density). g. post-prandial studies). However, cross-overs require more careful data analysis and interpretation. g. seasonal variation). Further guidance on designs is available in statistical texts on clinical trials [7–11]. g. turnover rates of tissues, such as erythrocytes). g. glycaemic response) or longer-term outcomes. Thus, no standards can be set for duration, but the aim should be to use the shortest feasible duration for ethical reasons, to conserve resources, and to avoid participant fatigue leading to non-compliance or withdrawal.
The conclusions should be justified by the data, relate directly to the hypothesis, food and the amount consumed, and the population studied. Conclusions about secondary outcome measures should be stated as such and interpreted appropriately. The final responsibility for interpretation and conclusions rests with the principal investigator irrespective of potential requests of a trial sponsor. g. industry funding, or financial or other conflicts of interest) are standard, and they are required by scien- 28 Woodside · Koletzko · Patterson · Welch Szajewska H, Shamir R (eds): Evidence-Based Research in Pediatric Nutrition.