By Icon Health Publications
This can be a 3-in-1 reference publication. It offers an entire clinical dictionary protecting hundreds of thousands of phrases and expressions in terms of methionine. It additionally supplies broad lists of bibliographic citations. ultimately, it offers info to clients on the way to replace their wisdom utilizing numerous net assets. The ebook is designed for physicians, scientific scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to familiarize yourself with examine devoted to methionine. in case your time is effective, this booklet is for you. First, you won't waste time looking the net whereas lacking loads of proper info. moment, the ebook additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing thousands of websites.
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Additional resources for Methionine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
We will test the hypothesis that posttranslational modifications affect the chaperone-target protein binding leading to reduced chaperone function. ; Professor and Chairman; Molecular & Cellular Biochemistry; Ohio State University 1960 Kenny Road Columbus, Oh 43210 Timing: Fiscal Year 2002; Project Start 01-APR-2002; Project End 31-MAR-2007 Summary: Epidemiological and clinical studies have demonstrated that folate deficiency in humans could lead to susceptibility to certain types of cancers. Premalignant dysplasia could be reversed by folate supplementation.
We will, in parallel, perform direct analysis of Met and HGF/SF in normal and tumor tissue by IP and western blot. g. drugs, radiation and hormones) and neutralizing antibodies to Met and HGF/SF for potential utilization of imaging technologies in human cancer. Specific Aims: 1. We will measure Met interaction with its ligand (HGF/SF) and its signal transduction substrates at the sub-cellular level using fluorescence tagged proteins. 2. We will develop molecular imaging techniques to determine in animal models, the presence of Met and HGF/SF, using fluorescence tagged proteins in xenograph tumors and in transgenic and "knocked in" animals.
In Specific Aim 3 will use 13C isomer spectroscopy to assess the effect of those compounds that cross the blood brain barrier (the GS inhibitor methionine sulfoximine and the glutamine transporter MeAIB) on glutamate-glutamine-GABA cycling in control animals. These experiments should provide important data on the regulation of normal synaptic transmission as well as an understanding of the pathology of a number of neurological disorders where changes in neural energetics have been seen including epilepsy, ALS and Huntington's disease.