By Sara Bobone
In her thesis, Sara Bobone outlines spectroscopic experiences of antimicrobial peptides (AMPs) that are promising lead compounds for medicinal drugs used to struggle multidrug resistant micro organism. Bobone indicates that AMPs engage with liposomes and he or she clarifies the constitution of pores shaped by means of this type of molecules. those effects aid us to appreciate how AMPs are selective for bacterial membranes and the way their job could be finely tuned through editing their series. Findings which clear up a number of conundrums debated within the literature for years. moreover, Bobone makes use of liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- meeting houses of phospholipids. Bobone was once capable of capture an enzyme utilizing nanometeric debris, whereas nonetheless permitting its job by way of the diffusion of substrates and items throughout the community of the polymer. The cutting edge nano units defined during this thesis may remedy a number of the hurdles nonetheless hampering the healing program of protein-based drugs.
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Extra info for Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery
0001 Fig. 24 CF leakage from ePC vesicles. Red, filled symbols: P5. 01 [Peptide]/[Lipid] The effect of cholesterol resulted to be negligible; for this reason, all the following experiments on peptide-induced membrane-perturbation were performed using PC/PG and PC/cholesterol liposomes only. 2 Vesicles Aggregation Liposomes-induced aggregation was investigated measuring the light scattering increment at 400 nm. 2 Selectivity 53 Fig. 25 Peptide-induced ePC/ePG vesicles aggregation. 03 0 0 100 200 300 [Lipid] (μM) Fig.
However, this bilayer deformation requires a free energy cost. Therefore, if a transmembrane orientation is involved in the GAIV pore-formation process, the membrane-perturbing activity of this peptide should increase significantly in thinner membranes, which require a smaller deformation or no thinning at all. To verify this point, peptide-induced vesicle leakage experiments have performed with liposomes formed by lipids with different chain lengths and bilayer thicknesses  (Figs. 15). For comparison, the same experiments were carried out also with the much longer peptaibol Alm (Fig.
E. in about 10–30 ns) some lipid headgroups in the region above and below the peptide were drawn deeper in the membrane, due to the interaction with the free peptide NH and CO groups at the two termini of the helices. A few structures representative of the time-evolution of the simulations are shown in Fig. 9, and the structures at the end of the simulations are illustrated in Fig. 10. To better define the interactions responsible for the observed bilayer deformation an analysis was carried out of the interactions of the peptide NH and CO groups not involved in intramolecular H-bonds, and of the OH group of the Cterminal amino alcohol, with different parts of the lipid molecules or with water.