By H. Huland (auth.), Professor W. B. Peeling, Professor Dr. med. Hermann Becker (eds.)
The growth made within the analysis of prostate carcinoma with the advent of transrectal ultrasound (TRUS), PSA decision, and ultrasound-guided prostate biopsy in addition to more suitable working innovations have resulted in a substantial bring up within the variety of radical prostate operations being played and therefore elevated the possibilities of luck of healing therapy in lots of sufferers. using neoadjuvant endocrine treatment prior to radical prostatectomy remains to be a question of dialogue. it is going to definitely basically be attainable to make a last judgement at the foundation of long term observations. This publication takes under consideration that merely a global alternate of recent findings can create the required stipulations for greater treatment.
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Extra info for Progress in Diagnostics and Therapy of Prostatic Cancer
W. Tunn et. al. 6 -S c.. 9 20 ---SE Ol T3c 15 « en 10 c.. 0 Start of CAD RRP 5J 63% ~iJ 37% Fig. 2 a,b. Drop in median serum PSA concentrations in patients with stage T3 prostate cancer after neoadjuvant CAD and radical prostatectomy (n=l13 of 147 patients) Fig. 3. 1 % respectively. 9 %). 4 % of the pT2 tumours. Neoadjuvant Androgen Deprivation 41 1,4% 25,8% Fig. 4. Clinical stage before neoadjuvant CAD related to histological stage of the surgical specimens 59% 53% 35% 30% 17% 6% J pT3 pT2 '-IO-R- (- R- II-0-··R-II-' )1 Fig.
Lancet 60-63 Mettlin C, Lee F, Drago J, Murphy GP (1991) The American Cancer Society National Prostate Cancer detection project. Findings on the detection of early prostate cancer in 2425 men. Can cer 67: 2949-2958 Resnick MI (1987) Editorial comments. In: Rattiff TL, Catalona WJ (eds) Genitourinary cancer. Martinus Nijhoff, Boston, pp 94-99 Rifkin MD, Zerhouni EA, Gatsonis CA, Quint LE, Paushter DM, Epstein JI, Hamper U, Walsh PC, McNeil B (1990) Comparison of magnetic resonance imaging and ultrasonography in staging early carcinoma of the prostate.
05). Recently, the Prostate Cancer Trialists' Collaboratic Group (1995) published the results of the metaanalysis partial vs complete or maximal androgen deprivation indicating no survival benefit for the latter. To conclude, it must be emphasized that the greatest advantage from complete androgen deprivation is obtained by patients with minimal metastasis (Table 7). It seems obvious that adjuvant therapy should also be reviewed in the light of this fact. Partial Versus Complete Androgen Deprivation 51 Table 6.