By Marek Pawlikowski
Somatostatin is a peptide remoted initially from the hypothalamus and thought of as an inhibitor of progress hormone secretion. besides the fact that, extra stories have proven that the peptide was once ubiquitously disbursed and exerts a wide spectrum of physiological results, in most cases of an inhibitory nature. The very brief half-life of the local peptide limits its healing software. to beat this drawback the enduring transformed molecules (analogs) of somatostatin have been synthesized. the current ebook offers entire info at the program of somatostatin analogs in diagnostics and therapy of ailments, typically endocrine issues and cancers.
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Extra resources for Somatostatin analogs in diagnostics and therapy
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49. Culler MD, Taylor JE, Kim S et al. Chimeric analogs of somatostatin in pituitary adenoma. Paper presented at: “Somatostatin analogs: A state of the art review,” a satellite symposium of the 5th European Congress of Endocrinology. Turin, Italy: 2001. 50. Saveanu A, Lavaque E, Gunz G et al. Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells. J Clin Endocrinol Metab 2002; 87:5545-52.
Endocrine Pathology 2003; 14:231-238, with permission of the editor. D) Neuroendocrine pancreatic cancer immunostained with anti-sst2A antibody (SS-800). Reproduced from Kunert-Radek J et al. Endokrynologia Polska Pol J Endocrinol 2004; 55:190-195, with permission of the editor. E) Neuroendocrine tumor (carcinoid) immunostained with anti-sst 5 antibody (SS-890). Positive immunostaining in the tumoral cells and vascular endothelia. F) Pheochromocytoma, metastasis to the liver. Strong immunostaining with the anti-sst3 antibody (SS-850).