By Masao Omata (auth.), Masao Omata M.D., Kiwamu Okita M.D., Ph.D. (eds.)
The first single-topic annual convention on hepatology in Japan used to be held in November 2002 to debate remedies for viral hepatitis and the prevention of hepatocellular carcinoma (HCC). Bringing jointly researchers and clinicians from North the USA, Europe, Japan, and different elements of Asia, the convention integrated symposia at the hepatitis C replicon approach, new antivirals that decrease or hinder the occurrence of HCC, and transplantation in instances of hepatitis B and C, in addition to new remedy modalities for viral hepatitis and preventative measures for HCC. With the emerging variety of HCC instances world wide, this number of papers provided on the convention offers a worthy, updated source and reference for all execs concerned about the therapy and prevention of viral hepatitis and hepatocellular carcinoma.
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The 1st single-topic annual convention on hepatology in Japan was once held in November 2002 to debate treatments for viral hepatitis and the prevention of hepatocellular carcinoma (HCC). Bringing jointly researchers and clinicians from North the US, Europe, Japan, and different components of Asia, the convention incorporated symposia at the hepatitis C replicon process, new antivirals that reduce or hinder the prevalence of HCC, and transplantation in instances of hepatitis B and C, in addition to new remedy modalities for viral hepatitis and preventative measures for HCC.
Additional info for Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma
Though larnivudine has negligible side effects, the long-term use of lamivudine may result in the emergence of drug resistant virus with mutations of the YMDD (tyrosine-methionine-aspartate-aspartate) motif at the C domain of the HBV polymerase gene. The methionine in the YMDD motif will either be substituted by isoleucine (YIDD) or valine (YVDD). The chance of YMDD mutation increases with the duration of treatment (15%, 38%, 56%, 67% and 69% for the first five years respectively). Though YMDD mutants have less replication competence than YMDD wild-type as demonstrated by some experimental studies [10,11], they can sometimes cause severe hepatic exacerbations [12,13].
10. Yokosuka 0, Ornata M, Imazeki F, Okuda K, Summers J. Changes of hepatitis B virus DNA in liver and serum caused by recombinant leukocyte interferon treatment: analysis ·of intrahepatic replicative hepatitis B virus DNA. Hepatology 1985;5:728734. 11. Lai CL, Chien RN, Leung NW, Chang IT, Guan R, Tai DI, Ng KY, Wu PC, Dent JC, Barber J, Stephenson SL, Gray DF. A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. N Engl J Med 1998;339:61-68. 12. Ornata M.
3. Median logarithmic reduction of HBV DNA levels in different groups of patients receiving lamivudine and / or LdT over 24 weeks Table 1. 05 vs. OI vs. 2 vs. OI). At week 24, there was no additional benefit with the combination therapy. Fig. 4 illustrates the median levels of residual viraemia at week 24. 2 logs. 2 log. It has already been noted above that a viral load of less than 10 3 copies/ml at 6 months of therapy is associated with a low chance of future development of viral resistance [14J.